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Circulating tumor cells (CTCs) are valuable biomarkers of disease and accessible through minimally invasive liquid biopsy methods, such as a simple blood draw. Unfortunately, the isolation, detection and analysis of CTCs is immensely challenging due to their extremely low abundance in whole. Indeed, only 1-10 CTCs are typically present in 1 mL of blood and are hidden by a background of billions of red blood cells, white blood cells and platelets. Currently, the CellSearch® in