Research Highlights

Calibration Free FCS

Biomolecular condensates formed through liquid–liquid phase separation play a key role in organizing cellular processes by locally concentrating macromolecules without membrane boundaries. The measurement of molecular concentrations and mobilities within condensates remains challenging due to the heterogeneous nature of such systems, with conventional fluorescence correlation spectroscopy (FCS) techniques requiring external calibration, limiting their application in phase-sep

deMello Group

Jan 191 min read

Easy Squeezy Transfection

Intracellular delivery techniques are used to deliver proteins, mRNA, plasmid DNA, and other cargos into cells and are central to a variety of gene- and cell-based therapies. Viral transduction and physical transfection methods such as electroporation are most commonly used, but are often compromised by poor delivery efficiencies and limited throughput. Mechanoporation via viscoelastic squeezing offers a promising alternative, leveraging physical forces to generate pores in t

deMello Group

Jan 82 min read

Advancing Climate Models by Microfluidic Nucleation Experiments

Mineral dust particles act as ice-nucleating particles and play a crucial role in weather and climate processes. Accurate understanding of these mechanics is required to improve and validate climate models, as the composition of atmospheric dust directly influences both precipitation and radiation behavior. Suspensions containing pure or binary mixtures of microcline, montmorillonite, or quartz have been investigated by Nadia Shardt and co-workers using the previously develop

deMello Group

Dec 19, 20251 min read