Development of Microfluidic Chip for Coronary Microvascular Disease
Coronary microvasculature is subjected to a plethora of diseases that are poorly understood and diagnosed. The systematic integration of microfluidics in the analysis of coronary microvascular disease (CMVD) is essential for a better understanding of the hemodynamic alteration and the consequent endothelial dysfunction leading to the pathological cardiac impairment.
Starting from the latest experimental set-up and chips microfabricated in our group, we herein propose to optimize the microvascular perfusion model through in-silico and/or in-vitro modelling, with the final goal of replicating with high-fidelity the pathological condition observed in-vivo through qualitative positron emission tomography images.
To achieve this goal, we will need to:
Optimize the perfusing system for a controlled hemodynamic stimulation;
Characterize the biomechanical and biocompatibility properties of the developed platform.
Prior knowledge of computational fluid dynamics and/or microfabrication is preferential.
Contact person:
Dr. Monika Colombo, monika.colombo@chem.ethz.ch